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Post by james on Oct 29, 2021 15:16:54 GMT -5
Report in Nature of a promising looking clinical trial. "A cheap, widely available drug used to treat mental illness cuts both the risk of death from COVID-19 and the need for people with the disease to receive intensive medical care, according to clinical-trial results1. The drug, called fluvoxamine, is taken for conditions including depression and obsessive–compulsive disorder. But it is also known to dampen immune responses and temper tissue damage, and researchers credit these properties for its success in the recent trial. Among study participants who took the drug as directed and did so in the early stages of the disease, COVID-19-related deaths fell by roughly 90% and the need for intensive COVID-19-related medical care fell by roughly 65%. “A major victory for drug repurposing!” Vikas Sukhatme at Emory University School of Medicine in Atlanta, Georgia, who studies drug repurposing, wrote in an e-mail to Nature. “Fluvoxamine treatment should be adopted for those at high risk for deterioration who are not vaccinated or cannot receive monoclonal antibodies.”" www.nature.com/articles/d41586-021-02988-4ETA - www.thelancet.com/journals/langlo/article/PIIS2214-109X(21)00448-4/fulltext
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Post by Shannon on Oct 29, 2021 15:29:49 GMT -5
I had not seen anything about this yet. This could be very useful, if subsequent data confirms effectiveness.
Let us hope it is not the next hydroxychloroquine or ivermectin (very useful drugs, but not for COVID).
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Post by aquaduct on Oct 29, 2021 16:00:17 GMT -5
The modern interpretation of the boy who cried wolf.
Big whoop.
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Post by james on Oct 29, 2021 16:21:08 GMT -5
I had not seen anything about this yet. This could be very useful, if subsequent data confirms effectiveness. Let us hope it is not the next hydroxychloroquine or ivermectin (very useful drugs, but not for COVID). There are, as you'd expect some caveats in the article. Fingers crossed!
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Post by Marshall on Oct 29, 2021 16:22:00 GMT -5
Fluvoxamine, is taken for conditions including depression - Side effects include repeated requests to hear the Archie's Greatest Hits.
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Post by james on Oct 29, 2021 16:33:37 GMT -5
I took it for a while a few years ago. Quite efficacious. No Archies effects to report thankfully. 🙂
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Post by coachdoc on Oct 29, 2021 17:03:47 GMT -5
The modern interpretation of the boy who cried wolf. Big whoop. That is a superficial and uninformed response to a potentially useful treatment.
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Post by millring on Oct 29, 2021 17:34:03 GMT -5
Since the right people are suggesting it, it's probably going to be the greatest thing since the hula hoop.
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Post by millring on Oct 29, 2021 17:37:13 GMT -5
I'm sitting here watching the nightly news on NBC. Holt is interviewing a doctor who is wearing a mask for no apparent reason. He's not in the room with Holt. He's at his own place and nobody is around him.
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Post by epaul on Oct 29, 2021 17:42:53 GMT -5
Shoot him.
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Post by TKennedy on Oct 29, 2021 17:53:44 GMT -5
I'm sitting here watching the nightly news on NBC. Holt is interviewing a doctor who is wearing a mask for no apparent reason. He's not in the room with Holt. He's at his own place and nobody is around him. i would guess he probably has a big festering zit on the end of his nose.
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Post by aquaduct on Oct 29, 2021 18:00:46 GMT -5
The modern interpretation of the boy who cried wolf. Big whoop. That is a superficial and uninformed response to a potentially useful treatment. As you and most of the rest of this board have done for the last almost 2 years.
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Post by aquaduct on Oct 29, 2021 18:04:41 GMT -5
I'm sitting here watching the nightly news on NBC. Holt is interviewing a doctor who is wearing a mask for no apparent reason. He's not in the room with Holt. He's at his own place and nobody is around him. He obviously got the Fauci memo.
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Deleted
Deleted Member
Posts: 0
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Post by Deleted on Oct 29, 2021 19:19:06 GMT -5
Sooooo f'ing predictive, this thread. Zzzzzzzzzzzz.
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Post by coachdoc on Oct 29, 2021 19:29:40 GMT -5
Sooooo @f'ing@ predictive, this thread. Zzzzzzzzzzzz. @predictable@
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Post by Cornflake on Oct 29, 2021 19:50:03 GMT -5
Certainly predictable, probably predictive.
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Post by Shannon on Oct 30, 2021 8:10:29 GMT -5
Since the right people are suggesting it, it's probably going to be the greatest thing since the hula hoop. Hey, who are these powerful "right people"? I'd like to meet them! Seriously, the guy in the news story from Emory seems more than a bit overly enthusiastic, and I'm not aware of any momentum to start putting high-risk patients on fluvoxamine. I read the Lancet study and checked the statistics. There were only about 1500 people enrolled in the study, so the numbers were not very big. I also have a big quibble with their definition of "intensive treatment." Using their numbers and their definitions, one would have to treat 20 patients with fluvoxamine to prevent 1 adverse outcome. As these things go, that's actually a pretty good number, and it would be interesting to see if it held up in a large study. The medical literature is full of encouraging findings in small early trials that did not hold up to further study, so count a me a skeptic on fluvoxamine for the moment. On the other hand, I would think that everyone would be happy if we could find a cheap, safe, and easily deliverable treatment for COVID. Finally, I never saw what was so great about hula hoops, anyway.
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Post by james on Oct 30, 2021 9:32:54 GMT -5
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Post by TKennedy on Oct 30, 2021 9:39:34 GMT -5
I read the study too and got some of the same vibes I got from the study that French physician did on Chloroquine early in the pandemic. It would be cool if it becomes a game changer but I am skeptical too. Hope I am wrong.
Plus it was in Brazil and rumor has it the treated group of patients in ICU were required to listen to a continuous loop of How Insensitive while the placebo group listened to Samba de Orfeu.
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Post by aquaduct on Oct 30, 2021 13:56:09 GMT -5
Oh, so pretty much like horse dewormer.
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